About froelich's syndrome
What is froelich's syndrome?
Froehlich syndrome is a constellation of endocrine abnormalities believed to result from damage to the hypothalamus, a part of the brain where certain functions such as sleep cycles and body temperature are regulated. Froehlich syndrome appears to be acquired while certain other disorders that resemble it, such as Prader-Willi syndrome, are genetic.
This syndrome appears to affect males mostly. The more obvious and frequently encountered characteristics are delayed puberty, small testes, and obesity. Teen-age boys with this disorder must be distinguished from those who have inherited growth delay disorders or Prader Willi syndrome.
What are the symptoms for froelich's syndrome?
Froehlich syndrome is characterized by increased or excessive eating that leads to obesity, small testes, and a delay in the onset of puberty. It is also common for children with Froehlich syndrome to experience the delay in physical growth and the development of secondary sexual characteristics. In addition to delayed growth and puberty, children with this syndrome tend to be Short in stature. As a result of tumor growth, some children with Froehlich syndrome may also develop intellectual difficulties, Poor vision – due optic nerve damage-, somnolence, and diabetes insipidus – known as Infundibulo-tuberal syndrome (Froehlich+somnolence+diabetes insipidus), lower than normal body temperature (hypothermia) and very delicate skin.
What are the causes for froelich's syndrome?
Froehlich syndrome (hypogonadism with obesity) results from an injury of a part of the hypothalamus (arcuatus nucleus and ventromedial nueclei. The hypothalamic gland is the endocrine gland that produces substances that stimulate the pituitary and regulate appetite. In Froehlich syndrome, the front portion (anterior) of the pituitary gland fails to secrete the hormones that are necessary for the onset of normal puberty.
The most frequent cause of Froehlich syndrome is a specific tumor of the pituitary-hypothalamus area, an expanding hollow (cystic) lesion (craniopharyngioma) or its surgical treatment (injury of this area during surgery).
Lesions resulting from inflammation from an infection such as tuberculosis or an acute inflammation of the brain (encephalitis) can also be responsible for causing Froehlich syndrome.
What are the treatments for froelich's syndrome?
Pituitary extracts may be administered through hormone replacement therapy (HRT) to replace the missing hormones in patients with Froehlich syndrome. For males, this usually includes administration of human chorionic gonadotropin to reach puberty followed up by testosterone. For females, HRT typically is the administration of estrogen during teenage years followed by complex estrogen-progestin therapy with age. If possible, tumors of the hypothalamus should be surgically removed if. Though appetite may be very difficult to manage, weight control depends on successful management. Some modern treatments can help to control obesity.
What are the risk factors for froelich's syndrome?
Froehlich syndrome is an unique childhood metabolic condition characterised by obesity, developmental delay, and slowed genital organ development. Here are the risk factors for Froehlich syndrome: Froehlich syndrome is caused by an injury to the hypothalamus. The hypothalamic gland is an endocrine gland responsible for stimulating the pituitary gland and regulating appetite. The front chunk of the pituitary gland struggles to secrete the hormones required for the onset of normal puberty in Froehlich syndrome. A specific pituitary-hypothalamic tumour is the most common cause of Froehlich syndrome. Due to the close linkage between the pituitary and the hypothalamus, the condition is most common in boys and may be linked to decreased pituitary function. Impaired vision can occur when a tumour presses against the optic nerve. Fröhlich's syndrome is treated by surgical removal of the tumour and dietary restriction until normal weight is achieved. It is usually linked with hypothalamic tumours, which cause increased appetite and decreased hormonal secretion. Several organic lesions of the hypothalamus can affect this acquired disorder.
Is there a cure/medications for froelich's syndrome?
Froehlich syndrome is a very rare condition that affects more males than females.