About neonatal progeroid syndrome

What is neonatal progeroid syndrome?

Wiedemann-Rautenstrauch syndrome (WRS), also known as neonatal progeroid syndrome, is a very rare genetic disorder characterized by an aged appearance at birth (old man look) growth delays before and after birth (prenatal and postnatal growth retardation), and deficiency or absence of the layer of fat under the skin (subcutaneous lipoatrophy). It is anticipated that most individuals with WRS have decreased life expectancy. Few individuals have lived well into their teens and afew still live in their 20s. WRS is inherited as an autosomal recessive trait, as several pairs of siblings have been reported in families with unaffected parents.



What are the symptoms for neonatal progeroid syndrome?

Mild to severe intellectual disabilityblood in e symptom was found in the neonatal progeroid syndrome condition

Neonatal progeroid syndrome is a rare genetic syndrome characterized by an aged appearance at birth. Other signs and symptoms include intrauterine growth restriction, feeding difficulties, distinctive craniofacial features, hypotonia, developmental delay and mild to severe intellectual disability. In most cases, affected infants pass away before age 7 months, but rare reports exist of survival into the teens or early 20s. 



What are the causes for neonatal progeroid syndrome?

Although the exact underlying cause of neonatal progeroid syndrome is unknown, it is likely a genetic condition that is inherited in an autosomal recessive manner. 



What are the treatments for neonatal progeroid syndrome?

Treatment is symptomatic and supportive.



What are the risk factors for neonatal progeroid syndrome?

Neonatal Progeroid syndrome, otherwise termed as Wiedemann-Rautenstrauch, is a rare genetic condition denoted by an aged appearance at the time of birth. Symptoms involve the growth restriction specific to the uterus, feeding ordeals, varying craniofacial features, hypotonia (low muscle tone), developmental impediments and mild to extreme intellectual disabilities.

Risk factors of Neonatal Progeroid Syndrome
1. It is a hereditary disorder, implying that it cannot in any way be avoided by following a checklist of what not to do. Recessive diseases such as Neonatal Progeroid syndrome is prominent in the child if two copies of a commonly mutated gene are passed on to the infant, one from each parent.
2. Risk remains constant in both males and females.
3. 25 percent is the risk for both carrier parents to bear the defective gene, at the rate of every infusion of the sperm and ovum.
4. 50 percent (a flat half chance) of the child inheriting it.
5. 25 percent chance that the child may inherit absolutely normal genes from both parents
Consanguineous parents (blood-related) are at higher risk.

Symptoms
An aged appearance at birth,Deficiency or absence of the layer of fat under the skin,Intrauterine growth restriction,Feeding difficulties,Distinctive craniofacial features,Hypotonia,Developmental delay,Mild to severe intellectual disability
Conditions
An aged appearance at birth,Subcutaneous lipoatrophy
Drugs
Therapies



Is there a cure/medications for neonatal progeroid syndrome?

With shortened life expectancy, aged appearance of the child, developmental delays (prenatal & postnatal retardation of growth), a hard time swallowing and feeding of food, deficiency or complete absence of the layer of fat called subcutaneous lipoatrophy underneath the skin, Neonatal Pregeroid syndrome stands as a rare hereditary condition. Growth is slowed down in the third trimester of the pregnancy.

Diagnosis can be done prenatally via ultrasound or promptly after the birth of the affected baby, relying on a detailed clinical evaluation and determination of physical characteristics. Other technologies that help detect this are X-ray reports, computer-assisted tomography, and magnetic resonance imaging.

Cure/medications of Neonatal Progeroid syndrome
1. No known cure exists. However, heart rates are regularly monitored along with the blood vessels. 2. Visits to the doctor will examine the weight and height, recording them on a chart of normal developmental values. Other factors are evaluated, for example:
-Electrocardiograms
-Dental
-Vision examination
-Hearing examination

Medications are as follows:
1. A low dosage of aspirin: A daily dose will lower the risk of heart attacks and strokes
2. Statins: Controls cholesterol
3. Prescribed drugs: Brings blood pressure under control
4. Anticoagulants: Helps to prevent blood clots
5. Other medications: Prescriptions to treat headaches and seizures
6. Good dental care

Symptoms
An aged appearance at birth,Deficiency or absence of the layer of fat under the skin,Intrauterine growth restriction,Feeding difficulties,Distinctive craniofacial features,Hypotonia,Developmental delay,Mild to severe intellectual disability
Conditions
An aged appearance at birth,Subcutaneous lipoatrophy
Drugs
Therapies



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